GHB and the Brain GHB, found endogenously in the brain, is a precursor of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) (Le & Richards, 2019). GHB affects both GABA-B and GHB receptors. GHB influences dopamine in a two-phase manner . At lower doses, it triggers the release of dopamine by interacting with GHB receptors. On the other hand, higher doses initially suppress dopamine release due to their agonist effects on GABA-B receptors, which results in neuro-inhibition and depression of the central nervous system (CNS). However, following this initial suppression, there is an increase in dopamine release via the GHB receptor. β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬β¬π©π©π©π©π©π©π©π©π©π©π©π© This dual action of GHB explains its sedative and excitatory effects. The primary concern with GHB toxicity is the depression of the central nervous system and respiratory system. π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯π₯ Substitutes for GHB, namely Gamma-butyrolactone and...
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