Neurobiological Components of Addiction: Understanding the Reward Pathway

 Neurobiological Components of

Addiction: Understanding the Reward

Pathway

Reward pathway

The basic concept in the neurobiology of addiction is the reward pathway which comprises the areas of the brain most involved in addiction. 

The limbic system

Home of the areas of the brain thought to make up the reward pathway. When stimuli activate particular areas of the brain then pleasurable sensations are produced. Neurotransmitters play critical roles in transmitting information between neurons through synapses. A synapse measures twenty to fifty nanometers.

Dopamine

Dopamine is an important neurotransmitter involved in reward and euphoria experiences. Dopamine is made by very few brain cells and acts mainly within a subset of brain regions. Dopamine seems to have a disproportionately large impact on brain function.

Cocaine

Cocaine interferes with the normal action of dopamine by blocking the removal or reuptake of dopamine which results in an increase of dopamine in the neurons, resulting in overstimulation of receiving neurons called neuroreceptors. This is experienced by the user as a pleasurable euphoria. An addict seeks to continue experiencing this sensation which results from an abundance of powerful neurotransmitters including dopamine. In the brain, this dopaminergic transmission and reward pathway is a primary feature of addiction.

The areas of the brain involved in the reward pathway

VTA

The VTA has emerged as a new research interest in understanding how addiction and drugs affect the brain. The stress of VTA may be a potential factor in relapse. Advanced research will unlock more keys to understanding the VTA and GABA's role in inhibiting or slowing the dopaminergic surge.

References 

     Capuzzi, D., & Stauffer, M. D. (2019). Foundations of Addictions Counseling (4th ed.). Pearson Education (US). https://bookshelf.vitalsource.com/books/9780135169858